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In people with alcohol-induced psychosis, neither comorbid misuse of cannabis nor hard drugs was significantly associated with increased all-cause mortality.

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Methods: To distinguish among these possibilities, we used the following pre- and postsynaptic markers of dendritic spines: Vglut1, specific to excitatory terminals of cortical origin; spinophilin, protein phosphatase 1 binding protein that is highly concentrated in spines; PSD95 and gephyrin, scaffolding proteins for excitatory and inhibitory synapses, respectively.

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Conclusion: Taken together, these observations suggest that (1) group differences in activation of neural substrates of WM storage emerge early in the sequence of cognitive events, with no evidence of accelerated decay in PSZ; and (2) the neural mechanisms that maintain items in WM storage may be qualitatively different between the two groups, as evidenced by the moderator effect of group on the relationship between K and alpha suppression during the delay period.

Participants with psychosis exhibited higher degree of physical disease burden, higher body mass index (BMI), and were more likely to be a smoker and to have substance dependence.

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Effects of high-intensity aerobic exercise on psychotic symptoms and neurocognition in outpatients with schizophrenia: study protocol for a randomized controlled trial.

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National Institutes of Health Clinical Center (CC); 2007.

Long-term treatment with low doses of antipsychotics is not a rare practice in clinical settings when treating bipolar patients.

Results: Preliminary data suggest an enhanced EA response in P180 in SZ as well as deficits in increasing the pain response in the PC by means of a decreased P3 and Late Positive Potential.

To be included, the patient had to have a baseline score of 42 or higher on the Brief Psychiatric Rating Scale and a score of 4 or higher on at least one positive symptom item of the Positive and Negative Syndrome Scale.

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Abelson helper integration site 1 knockout mice and stress resilience.

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Methods: Methods: A series of case-control experiments will be reviewed where we have used variants of simple visual change detection and change localization tasks to estimate WM capacity and the role of selective attention in WM encoding.

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Laboratory studies are used to assess severity and complications or rule out other diagnostic possibilities.

One way to exclude antipsychotic medication use as a confounding factor is to compare antipsychotic-naive schizophrenia patients with healthy volunteers.

Although the role of dopamine in sensory learning is still unclear, our findings suggest a possible pathway through which abnormal functioning of the associative striatum (due to excess dopamine transmission) could impact sensory functioning of auditory cortex, leading to hallucinations and perhaps other psychotic symptoms.

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We will discuss the study design advantages of large pedigrees, present new statistical genetic approaches we are developing to study rare variants, and show results from exome and gene expression screens in multiplex schizophrenia (SCZ) pedigrees from the Multiplex-Multigenerational Genetic Investigation (MGI) study.

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Linear mixed-effects models estimated the 2-year course of functioning in HCs vs.

The right amygdala, right piriform cortex and entorhinal cortex were positively correlated with odor identification score, and negatively correlated with CSAS and CPAS scores.

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The North American Prodrome Longitudinal Study is exploring whether the incorporation of biologic measures into prediction algorithms can provide more accurate identification of young people who are at greatest risk for developing a psychotic disorder.

For example, a youngster with ASD may do well on the parts of the test that measure visual skills but earn low scores on the language subtests.

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Non-pharmacological treatment can benefit key aspects of SZ disability.

This was also observed after restricting to those without significant physical health conditions, although Hispanic and “other” youths were not more likely than non-Hispanic whites to belong to the “mania only” class.

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Findings represent a bottom-up disruption pathway for deficit functioning, and suggest selective network-level involvement specific to individual aspects of NS.

It appears to be much less common with other SGAs, but has been reported with the use of olanzapine and ziprasidone (Geodon) at high dosages.

Background: Social cognition has been identified as a potential treatment target for interventions aimed at improving social functioning in schizophrenia.

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Results: The ESM was completed by 51 cases, 46 ARMS, and 53 controls.

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IS POOR ANTISACCADE PERFORMANCE IN HEALTHY FIRST-DEGREE RELATIVES OF SCHIZOPHRENICS AN ARTIFACT OF STUDY DESIGN?

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MMN to pattern deviants in the disorder.

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In most patients hyperglycemia occurred within three months of the start of risperidone therapy.

We sought to determine whether implicit processing of overt and subtle social threat cues would be intact in patients and whether that ability may be related to paranoid ideation.

Users of this guideline should be aware that we have also created separate guidelines on the management of SGA related metabolic and neurological complications that are detected over the course of monitoring procedures (in press).

Psychological Symptoms Associated with Cardiovascular Drugs; Cardiac Symptoms from Psychiatric Drugs; Drug Interactions.

Results: In single marker analyses the rs10835210 mutant A allele was significantly associated with schizophrenia.

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This guideline attempts to build on previous work in the area of SGA monitoring (; ) by providing a systematic review of the evidence and linking monitoring recommendations to the level of evidence.

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Antipsychotic treatment itself, however, may suppress (or partially suppress) the signs and symptoms of the syndrome and thereby may possibly mask the underlying process.

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Subsequently, we used this approach to study a separate group of 19 subjects with schizophrenia (10 with and 9 without history of adolescent cannabis abuse) and 13 HCs.

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Despite being abnormally elevated, higher theta power was correlated with better task performance, with greater Pd amplitude on color matching distractor trials, and with increased working memory capacity, exclusively in PSZ.

Antipsychotic Drug-Induced Somnolence: Incidence, Mechanisms, and Management.

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