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This period of time is called perimenopause or the menopausal transition, and its a time of hormonal imbalances, most notably when estrogen production by the ovaries begins to decline.

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Andrew Dillon, chief executive of NICE, said the regulator was disappointed that Roche has not lowered the price enough for it to be recommended for NHS use.

Continuous positive airway pressure reduces risk of motor vehicle crash among drivers with obstructive sleep apnea: systematic review and metaanalysis.

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